منابع مشابه
Nuclear pores and nuclear assembly.
Communication between the nucleus and cytoplasm occurs through large macromolecular structures, the nuclear pores. Quantitative scanning transmission electron microscopy has estimated the mass of a nuclear pore to be 60 million Daltons in yeast and 120 million Daltons in vertebrates. The past two years were noteworthy in that they saw: 1) the purification of both the yeast and vertebrate nuclea...
متن کاملOctagonal Nuclear Pores
Negative staining of isolated nuclear envelopes by phosphotungstate shows that the nuclear pores are octagonal rather than circular. Pores of the same shape and approximately the same width, 663 +/- 5 A, were demonstrated in the newt, Triturus, the frog, Rana, and the starfish, Henricia. The outer and inner diameters of the annulus associated with each pore are respectively greater and less tha...
متن کاملThe Permeability of Reconstituted Nuclear Pores Provides Direct Evidence for the Selective Phase Model
Nuclear pore complexes (NPCs) maintain a permeability barrier between the nucleus and the cytoplasm through FG-repeat-containing nucleoporins (Nups). We previously proposed a "selective phase model" in which the FG repeats interact with one another to form a sieve-like barrier that can be locally disrupted by the binding of nuclear transport receptors (NTRs), but not by inert macromolecules, al...
متن کاملThe path of RNA through nuclear pores
The nuclear pore acts as a gate in the nuclear envelope that permits exchange of macromolecules between nucleus and cytoplasm (reviewed by Akey, 1995; Bastos et al., 1995; Davis, 1995; Panté and Aebi, 1996; Mattaj and Englmeier, 1998; Yang et al., 1998). It is a huge wheel-like assembly (>1 MDa) of multiple copies of >100 different proteins arranged with eightfold symmetry. A central transporte...
متن کاملViruses Challenge Selectivity Barrier of Nuclear Pores
Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows facilitated entry of selected cargos, whose size can reach up to 39 nm. The translocation of large molecules is facilitated by nuclear transport...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1999
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(99)76883-9